Chemists Identify Key Mechanistic Step in Biosynthesis of Carbapenem Antibiotics

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Chemists Identify Key Mechanistic Step in Biosynthesis of Carbapenem Antibiotics

A team of researchers, including Carnegie Mellon University’s Yisong Guo, have revealed a key mechanistic step in the biosynthesis of carbapenems, a class of antibiotics used to treat some of the most serious drug-resistant bacterial infections. Understanding the chemical pathways that underlie the natural production of these molecules could help researchers develop new variants of antibiotics.