Energetic gene switch

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Reporting in Proceedings of the National Academy of Sciences, James Galligan, PhD, Lawrence Marnett, PhD, and colleagues demonstrate the existence of a previously undetected histone modification derived from glycolysis, the breaking down of glucose in the liquid part of the cell without oxygen to produce energy. Histone modifications by the glycolytic side-product methyglyoxal (MGO) can significantly alter the expression of numerous genes.