An international research team including scientists from Vanderbilt University has discovered how the diabetes drug metformin blocks glucose production by the liver. The discovery, reported Aug. 27 in the journal Nature Medicine, could lead to development of new ways to treat type 2 diabetes.
“The most common drug to manage type 2 diabetes is metformin,” said David Wasserman, PhD, Annie Mary Lyle Professor of Molecular Physiology and Biophysics at Vanderbilt University School of Medicine, who contributed to the study.
“Even though it is under wide usage and the most effective therapy in most patients, the mechanism of metformin action had been unclear,” Wasserman said. “These studies define the site-specific mechanism of action of metformin on blood glucose control.”